The molecular complexity of triple-negative/basal-like BC poses major challenges for the implementation of targeted therapies, and chemotherapy remains the standard approach at all stages. Triple-negative/basal-like breast cancer (BC) is characterized by aggressive biological features, which allow relapse and metastatic spread to occur more frequently than in hormone receptor-positive (luminal) subtypes. In summary, these results suggest that Cyr61 may play a role in the progression of breast cancer and may be involved in estrogen-mediated tumor development. Moreover, overexpression of Cyr61 in MCF-12A normal breast cells induced their tumor formation and vascularization in nude mice. Stable expression of Cyr61 cDNA under the regulation of a constitutive promoter in MCF-7 cells enhanced anchorage-independent cell growth in soft agar and significantly increased tumorigenicity and vascularization of these tumors in nude mice. Induction of Cyr61 mRNA was blocked by tamoxifen and ICI182,780, inhibitors of the estrogen receptor. Interestingly, expression of Cyr61 mRNA increased 8- to 12-fold in MCF-12A and 3- to 5-fold in MCF-7 cells after 24- and 48-h exposure to estrogen, respectively. Univariate analysis showed a significant or borderline significant association between Cyr61 expression and stage, tumor size, lymph node positivity, age, and estrogen receptor levels. Northern analysis revealed that Cyr61 was expressed highly in the invasive breast cancer cell lines MDA-MB-231, T47D, and MDA-MB-157 very low levels were found in the less tumorigenic MCF-7 and BT-20 breast cancer cells and barely detectable amounts were expressed in the normal breast cells, MCF-12A. Differential screening of the library isolated the growth factor-inducible immediate-early gene Cyr61, a secreted, cysteine-rich, heparin binding protein that promotes endothelial cell adhesion, migration, and neovascularization. Commercial areas like Dior(BON TON BILLLINGS), Samsonite are ideal places to buy souvenirs.To identify genes involved in breast cancer, polymerase chain reaction-selected cDNA subtraction was utilized to construct a breast cancer-subtracted library. You can also visit top-rated attractions like Yellowstone Art Museum, Doc Harper's, The Moss Mansion. If you want to spend a fun vacation with your family, locals recommend visiting Pryor Mountains. If you stay at a hotel in downtown Billings, nearby attractions like Western Heritage Center can be your first stop. If you're still unsure, recommends Hilton Garden Inn Billings. Red Lion Hotel Billings is one of the most popular hotels in Billings. Those who favor Howard Johnson can choose a hotel under its name. Hotels under the Howard Johnson brand are a good choice. As a popular tourist city, Billings has many renowned chain hotels. There are 19 two-star hotels in Billings at an average price of 83 USD per night. There are 22 three-star hotels in Billings at an average price of 114 USD per night. There are 2 four-star hotels in Billings at an average price of 141 USD per night. When looking for hotels in Billings, there are likely good options at a nightly budget of just 100 USD. There are 45 hotels in Billings with excellent service. You can plan a one or two day trip to Billings.Įvery day, travelers worldwide arrive at Billings Logan International Airport to start their vacations and business trips in Billings. If you travel to United States, visiting Billings is a good choice. Book your hotel on for an amazing travel experience. Looking for hotels in Billings? is a great place to start.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |